Sotalol
Sotalol is a dual-action cardiovascular agent possessing both Class II (beta-adrenergic blocking) and Class III (cardiac action potential duration prolonging) antiarrhythmic properties. Because it can cause life-threatening ventricular arrhythmias associated with QT prolongation, sotalol therapy must be initiated or up-titrated in an inpatient setting equipped with continuous ECG monitoring and cardiac resuscitation facilities.
Dosage by Body Weight
Adult dosing usually starts at 80 mg orally twice daily. Dosage adjustments are made gradually every 3 days based on clinical response, heart rate, QT interval, and renal function (creatinine clearance).
- Body Weight
- Below 5 kg
- Dose
- Strictly individualized
- Frequency
- 2 to 3 times daily as prescribed
- Tracking Notes
- Must be calculated using pediatric Body Surface Area (BSA) formulas with age-appropriate down-titration (for infants under 2 years) under inpatient pediatric cardiology supervision.
- Body Weight
- 5-7 kg
- Dose
- Strictly individualized
- Frequency
- 2 to 3 times daily as prescribed
- Tracking Notes
- Dose is strictly calculated based on Body Surface Area (BSA) and renal clearance. Requires in-hospital ECG monitoring during initiation.
- Body Weight
- 8-10 kg
- Dose
- Strictly individualized
- Frequency
- 2 to 3 times daily as prescribed
- Tracking Notes
- Requires pediatric oral solution formulations for highly accurate dosing.
- Body Weight
- 11-15 kg
- Dose
- Strictly individualized
- Frequency
- 2 to 3 times daily as prescribed
- Tracking Notes
- Dosing frequency and amount are tailored dynamically according to QTc interval and renal function.
- Body Weight
- 16-20 kg
- Dose
- Strictly individualized
- Frequency
- 2 to 3 times daily as prescribed
- Tracking Notes
- Dose must be converted from adult standards using established pediatric Nomograms (BSA-based scaling).
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Strictly individualized | 2 to 3 times daily as prescribed | Must be calculated using pediatric Body Surface Area (BSA) formulas with age-appropriate down-titration (for infants under 2 years) under inpatient pediatric cardiology supervision. |
| 5-7 kg | Strictly individualized | 2 to 3 times daily as prescribed | Dose is strictly calculated based on Body Surface Area (BSA) and renal clearance. Requires in-hospital ECG monitoring during initiation. |
| 8-10 kg | Strictly individualized | 2 to 3 times daily as prescribed | Requires pediatric oral solution formulations for highly accurate dosing. |
| 11-15 kg | Strictly individualized | 2 to 3 times daily as prescribed | Dosing frequency and amount are tailored dynamically according to QTc interval and renal function. |
| 16-20 kg | Strictly individualized | 2 to 3 times daily as prescribed | Dose must be converted from adult standards using established pediatric Nomograms (BSA-based scaling). |
Formulation
Purpose
Used to treat and prevent ventricular arrhythmias, and to maintain normal sinus rhythm in patients with highly symptomatic atrial fibrillation or atrial flutter.
Generic Name
Sotalol HydrochlorideBranded Drug Names
Sotalol is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.